The Best Performance of the Combined CAL-B/VOSO4 System Depending on the Good Mutual Coordination of Reactions

Enantiomerically pure secondary alcohols were prepared in the combined CAL-B/VOSO4 system one-pot conditions. Under optimum conditions, conversion, enantiomeric excess, selectivity and enantioselectivity reached 92%, >99%, 99% >200 respectively. The significant improvement of performance should be attributed to mutual coordination reactions a chemoenzymatic dynamic kinetic resolution reduction by-reaction. In conclusion, our experimental data literature confirm that there must an optimal amount V-MPS (VOSO4) coordinate in-situ racemic reaction with which enantiomer required is produced adverse producing minimize rate side substrate was consumed reduced, resulting DKR system. Considering large activation energy at least 76% excess catalytic capacity VOSO4, strategy adopted greatly reduce thus condition established, making optimal.